Ceska Gynekol. 2002 Nov;67(6):320-3.
Photodynamic therapy of benign viral vulvar lesions
HPV Virus Scientific Research - Article in Czech
Uhlir M, Jirsa M, Otcenasek M, Halaska M, Feyereisl J. Gynekologicko-porodnicka klinika, UK, 1. LF a FN Na Bulovce, Praha.
OBJECTIVE: The aim of the study was to evaluate the use of the photodynamic effect in the treatment of genital warts in women. DESIGN: Prospective study. SETTING: Department of Obstetrics and Gynecology, Hospital Na Bulovce, 1st Faculty of Medicine, Charles University, Prague. METHODS: Twenty-five women with genital warts (HPV infection), which were verified by biopsy, were involved into the study. The affected area was treated by ten milligrams of the 5-aminolevulinic acid in three milliliters of gel for 8 hours. Red light with the 630 nanometers wavelength was applied for 15 minutes, with calculated energy intake 30 J/cm2. RESULTS: All women were free of symptoms and had negative colposcopy in the followed period of 3 to 12 months. On average 3.8 sessions were necessary to reach the remission. It was possible to repeat the session after two weeks time. During the application of light, 17 (68%) of the patients felt either no or slight burning sensation, 6 (24%) had unpleasant but bearable sensation and 2 patients had to be treated in short intravenous anesthesia. CONCLUSION: Photodynamic therapy (PDT) is a promising modality in the treatment of HPV vulvar lesions and can be considered to be a method of choice.
Am J Perinatol. 2003 Jan;20(1):11-6.
Evidence for the presence of neutralizing antibodies against human papillomavirus type 6 in infants born to mothers with condyloma acuminata.
Kawana K, Yasugi T, Yoshikawa H, Kawana Y, Matsumoto K, Nakagawa S, Onda T, Kikuchi A, Fujii T, Kanda T, Taketani Y. Department of Obstetrics and Gynecology, Faculty of Medicine, University of Tokyo, Bunkyo-ku, Tokyo, Japan.
Despite human papillomavirus type 6 or 11 (HPV6/11) being often vertically transmitted from mothers with condyloma acuminata (CA) to their infants, HPV-related neonatal mucosal diseases are rare. The role of maternal anti-HPV6/11 neutralizing antibodies in preventing the vertical transmission remains to be unknown because of lack of the neutralization assay system of HPV infection. We experienced two cases of HPV6-positive CA during pregnancy. Neutralizing antibodies against HPV6 in maternal, umbilical, and infantile sera were determined using a surrogate assay system to monitor HPV6 pseudo-infections. The neutralizing antibodies were detected in maternal and umbilical sera and in serum of one of the infants tested at 5 weeks old. In the infant exposed to HPV6 at birth, viral DNA was not detectable in the oral cavity 5 weeks after birth. This is the first report to describe that neutralizing antibodies against HPV6 in mothers with CA go through the placenta and enter the circulation of their infants. These data may provide a mechanistic paradigm for the prevention of its vertical transmission.
Publication Types: - Case Reports
Arch Gynecol Obstet. 2003 Feb;267(4):263-5. Epub 2003 Jan 23.
Condylomata gigantea in anal and perianal region: surgical and CO2 laser treatment.
Perisic Z, Lazic JP, Terzic B, Perisic S, Rasic R. OB/GYN Clinic Narodni front, Belgrade, Yugoslavia. eterna@eterna.co.yu
CASE REPORT: We present a case of 28-year-old female patient with condylomata gigantea (Buschke-Lowenstein tumor) in anal and perianal region with propagation on vulva and vagina. The local surgical excision and CO(2) laser treatment were performed. Histological examination showed presence of HPV type 11 without malignant potential. RESULT: Three months later, there was no recurrence.
Publication Types: - Case Reports
Cleve Clin J Med. 2002 Dec;69(12):948, 951-5, 956 passim.
Update on the diagnosis and treatment of human papillomavirus infection.
Zanotti KM, Belinson J. Section of Gynecologic Oncology, Department of Obstetrics and Gynecology, The Cleveland Clinic Foundation, OH 44195, USA. zanottk@ccf.org
Human papillomaviruses (HPVs) are associated with a spectrum of diseases, ranging from common warts to invasive carcinoma of the genital tract. The clinical manifestations of HPV infection depend on the viral subtype, the immune status of the patient, and environmental co-carcinogens. Infection with HPV is often asymptomatic, which makes viral detection challenging. Current therapies do not reliably eradicate HPV infection, and benign genital warts and genital tract intraepithelial neoplasia often recur after treatment. We discuss the pathogenesis, clinical manifestations, detection, and treatment of HPV infections of the anogenital tract.
Publication Types: - Review
- Review, Tutorial
HPV Virus Scientific Research - Therapy for HPV Links
HPV Infections Treated Naturally
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Human Papillomavirus Threats
- A scientific research on relations between HPV and cancer.
Sex and STDs: Gene Therapy
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